Molecular Formula | C22H27FN4O2 |
Molar Mass | 398.47 |
Density | 1.18±0.1 g/cm3(Predicted) |
Melting Point | 160-163 °C |
pKa | 1.08±0.40(Predicted) |
In vivo study | [18F]DPA-714 binding significantly increases in vivo as a result of AD‐like pathology and age in APP swe ×PS1 Δe9 mice. |
Biological activity | DPA-714 is a high-affinity translocation protein (TSPO) ligand (Ki = 7 nM). There is a fluorine atom in the structure of the DPA-714, which allows Fluoro -18 is used for labeling, and positron emission tomography can be used for in vivo imaging. 18FDPA-714 successfully evaluated specific imaging of inflammation in various neuroinflammatory models and brain tumor models. |
target | Ki: 7 nM (TSPO) |